The Investigation of Lectin-Like Oxidized LDL Receptor 1 (LOX-1) K167N Polymorphism, Inflammation, and Lipid Status in Patients with Coronary Artery Bypass Grafting

Objective: Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. Besides traditional risk factors, genetic factors such as single nucleotide polymorphs (SNPs) can be involve process. Inflammation plays role changes throughout atherosclerosis, initiation to progress. In this study, we aimed evaluate effects of lectin-like oxidized LDL receptor 1 (LOX-1) K167N polymorphism, inflammation, and lipid status patients with bypass grafting (CABG). Material Methods: The study population consisted 129 CAD who had undergone CABG, 71 healthy controls. LOX-1 polymorphism was genotyped using PCR-RFLP technique. Plasma interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), interleukin-33 (IL-33) levels were determined by enzyme-linked immunosorbent assay (ELISA) kits. Results: distribution genotypes alleles did not differ significantly between CABG There no significant differences plasma IL-1β, TNF- α, IL-33, HDL-C, LDL-C IL-1β systolic blood pressure values higher KK genotype compared same controls(P<0.05). Similarly, pressures NK controls (P<0.01). Conclusions: found post while inflammatory markers profiles selected according allele distributions groups. Although couldn’t find an assocation other than high BP our studies larger sample sizes might reveal relation.